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Tuesday, April 28, 2020 | History

4 edition of Progress in the reduction, refinement, and replacement of animal experimentation found in the catalog.

Progress in the reduction, refinement, and replacement of animal experimentation

World Congress on Alternatives and Animal Use in the Life Sciences (3rd 1999 Bologna, Italy)

Progress in the reduction, refinement, and replacement of animal experimentation

proceedings of the 3rd World Congress on Alternatives and Animal Use in the Life Sciences, held in Bologna, Italy, from 29 August to 2 September 1999

by World Congress on Alternatives and Animal Use in the Life Sciences (3rd 1999 Bologna, Italy)

  • 143 Want to read
  • 39 Currently reading

Published by Elsevier Science B.V. in Amsterdam, New York .
Written in English

    Subjects:
  • Alternative toxicity testing -- Congresses

  • Edition Notes

    StatementM. Balls, A-M. van Zeller, and M.E. Halder
    GenreCongresses
    SeriesDevelopments in animal and veterinary sciences -- 31A-31B
    ContributionsBalls, Michael, Zeller, A-M., Halder, M. E.
    Classifications
    LC ClassificationsRA1199.4.I5 W67 1999
    The Physical Object
    Pagination2 v. (xxvii, 1795 p.) :
    Number of Pages1795
    ID Numbers
    Open LibraryOL18118358M
    ISBN 100444505296
    LC Control Number00042978


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Progress in the reduction, refinement, and replacement of animal experimentation by World Congress on Alternatives and Animal Use in the Life Sciences (3rd 1999 Bologna, Italy) Download PDF EPUB FB2

Progress in the reduction, refinement and replacement of animal experimentation: Proceedings of the 3rd World Congress on Alternatives and Animal Use in the Life Sciences, Bologna, Italy, 29 August to 2 September, Cited by: 3.

Progress in the reduction, refinement, and replacement of animal experimentation: proceedings of the 3rd World Congress on Alternatives and Animal Use in the Life Sciences, held in Bologna, Italy, from 29 August to 2 September progress in the reduction, refinement and replacement of animal experimentation: proceedings of the 3rd world congress on alternatives and animal use in the life sciences, held in bologna, italy, from 29 august to 2 september Accelerating progress in the Replacement, Reduction and Refinement (the Three Rs) of animal testing through better knowledge sharing Abstract The replacement, reduction and refinement of the use of animals in science are legal requirements under EU Size: 2MB.

The National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) was set up in UK in as an independent organization and is responsible for supporting animal experimentation in the UK through the application of the principles of replacement, refinement, and reduction (3Rs).

In the context of the European Commission's Communication published in response to the European Citizens' Initiative "Stop Vivisection", Action 1 aimed to conduct an assessment of current technologies, information sources and networks from all relevant sectors with potential impact on the advancement of the refinement, reduction and replacement of animals used for scientific purposes (the.

Similarly, the adoption of testing of substance on cells in culture, as opposed to living animals, is a replacement strategy that could also be considered both a reduction and refinement strategy as it reduces the number of animals used and minimizes the harm experienced by those animals.

3Rs alternatives refer to the reduction, refinement, and replacement of animal use in research, testing, and teaching. The concept was developed by Russell and Burch in a book entitled Principles of Humane Experimental Technique (link is external).

WMS Russell and RL Burch originated the concepts of replacement, reduction, and refinement, which they published in their book in entitled “The Principles of Humane Experimental Technique” [].Russell and Burch proposed that if animals were to be used in experiments, every effort should be made to ‘Replace’ them with non-sentient alternatives, to ‘Reduce’ to a minimum number of Author: Arvind D.

Ingle. Replacement, Reduction and Refinement* Paul Flecknell Comparative Biology Centre, Medical School, University ofNewcastle, Newcastle upon UK-Tyne *Presentation at a symposium "Use of animals in research: ascience-society controversy?" held by the Doerenkamp-Zbinden-Foundation on March 12in D-Mainz.

This presentation will also be published in File Size: 3MB. This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs.

Russell and Burch introduced the principles of replacement, reduction, and refinement of animal experimentation in in their groundbreaking book, The Principles of Humane Experimental Technique (Russell and Burch, ). Their highest goal was to avoid the use of animals wherever possible, and—in cases where animals were still deemed indispensable—to significantly enhance their treatment while.

The replacement, reduction and refinement of the use of animals in science are legal requirements under EU legislation. The sharing of knowledge in this area is crucial not only towards the goal of full replacement but also to advance the scientific tools.

This report assesses how this knowledge is currently shared and proposes options towards enhancing knowledge sharing. Replacement: methods which avoid or replace the use of animals in research; Reduction: use of methods that enable researchers to obtain comparable levels of information from fewer animals, or to obtain more information from the same number of animals.

Progress is being made in reducing the number of animals used in testing. Testing involves the use of animals, primarily rats and mice, to assess the safety or effectiveness of consumer products such as drugs, chemicals, and cosmetics. Many researchers are now searching for ways to further reduce the use of animals in testing, and these efforts.

About the NC3Rs The National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) is a Government-backed independent scientific e-led and evidence-based, the NC3Rs funds research and early career awards, fosters collaborations between universities and industry to develop and commercialise 3Rs technologies, and provides information on.

§ 9 Replacement, reduction and refinement Live animals should not be used in experiments if the purpose can be achieved by replacing such use with alternative methods or testing strategies.

No more animals should be used in an experiment than is necessary to achieve the purpose of the experiment. Kathrin Herrmann is a veterinarian and expert for animal welfare science, ethics and law with focus on the 3Rs of animal experimentation.

She currently works for the Center for Alternatives to Animal Testing (CAAT) at Johns Hopkins University, MD, USA. Kimberley Jayne, PhD, has over a decade of research and educator experience working to enhance the welfare of animals in laboratory and.

1 Introduction [R]efinement is never enough, and we should always seek further for reduction and if possible replacement.

russell and burch,Chapter 4. Russell and Burch introduced the principles of replacement, reduction, and refinement of animal experimentation in in their groundbreaking book, The Principles of Humane Experimental Technique, to eradicate Author: Kathrin Herrmann.

animal experimentation: en: : progress in the reduction, refinement and replacement of animal experimentation: proceedings of the 3rd world congress on alternatives and animal use in the life sciences, held in bologna, italy, from 29 august to 2 september en: ance.

Read more: The UK National Centre for the Replacement, Refinement and Reduction in Animals in Research (NC3Rs) is an independent scientific organisation tasked by Government to fund innovation and technological developments that replace or reduce the need for animals in research and testing, and lead to improvements in welfare where animals.

Russell and Burch introduced the principles of replacement, reduction, and refinement of animal experimentation in in their groundbreaking book, The. The third of the 3R's – Refinement is any decrease in the incidence or severity of 'inhumane' procedures applied to those animals that still have to be used.

There are two key issues: To assess the impact of any procedure or condition on the well-being of the animal; Strategies to. Aware of the potential importance of their work and how a system can lend insight into how to prevent and cure illness, scientists follow the three Rs in order to reduce the impact of research on animals: Reduction, Refinement, Replacement.

Reduction: Reducing the number of animals used in experiments by: Improving experimental techniques. Get this from a library. Animal experimentation: improvements and alternatives: replacement, refinement, and reduction. [Norman Marsh; Susan Haywood; Fund for the Replacement of Animals in Medical Experiments.; Liverpool Animal Ethical Group (Liverpool, England);].

Reduce, Refine, Replace: The Failure of the Three R's and the Future of Animal Experimentation Darian M Ibrahimt The debate in animal ethics is defined by those who advocate the regulation of animal use and those who advocate its aboli-tion.' The animal welfare approach, which focuses on regulating.

Replacement is the option that is most attractive to animals lovers and politicians and has been actively promoted by the Fund for Replacement of Animals in Medical Experimentation () and the European Centre for the Validation of Alternative Methods, which was set up by the European Union.

4,5 Replacement can be relative Cited by: This paper reviews the progress achieved in the replacement of animal use by non-animal methods, with a focus on regulatory testing. In addition, it presents evidence of a reduction in the numbers. What are the moral and ethical dimensions of animal research.

What obligations do we have toward our animal subjects. In this important new book, students, researchers, and interested general readers will find a non-intimidating, readily comprehensible introduction to all the principal ethical issues and arguments in the animal experimentation debate.5/5(1).

Animal welfare guidelines and legislation still emphasise Russell and Burch's () `three Rs': reduction (of the number of animals used), refinement (of testing procedures to minimise suffering.

The 3 R's represent reduction in the number of animals used, refinement of techniques and procedures that reduce pain and distress, and replacement of animal with non-animal techniques.

The first step in conducting a search for alternatives, involves communication between the investigator and the information specialist. FRAME'S contributions to progress based on the Three Rs (replacement, refinement, reduction) concept of alternatives are reviewed, with particular emphasis on FRAME'S journal ATLA (Alternatives to Laboratory Animals), the work of the FRAME Toxicity Committee, the FRAME Research Programme, the British Animals (Scientific Procedures) Act and Cited by: 6.

which promotes and sustains public confidence that animal based research is acceptable and being appropriately managed. Key words: 3Rs: Replacement: Reduction: Refinement: Reproducibility: Environmental enrichment There is a presumption that, at some point in the future, the need to use animals in research will come to an end.

However. Process for developing humane endpoints for toxicity testing. Reprinted with permission from Stokes WS. Humane endpoints for laboratory animals used in toxicity testing. In: Balls M, van Zeller AM, Halder M, eds. Progress in the Reduction, Refinement, and Replacement of Animal Experimentation.

Amsterdam: Elsevier, ρ Cited by: Hume's predictions regarding the book's impact have been realized as the concepts of replacement alternatives, reduction alternatives, and refinement alternatives have become established in law.

However, at the present time, a thorough working knowledge and acceptance of the principles of humane experimental technique among scientists in. The TNPRC is committed to the humane care and use of animals and adheres to the principles of humane animal experimentation proposed by Russell and Burch in their book The Principles of Humane Experimental Technique ().

These principles, commonly referred to as the Three R's and defined as reduction, refinement and replacement, were proposed as key strategies to provide a systematic.

Alternatives to animal testing are the development and implementation of test methods that avoid the use of live animals. There is widespread agreement that a reduction in the number of animals used and the refinement of testing to reduce suffering should be important goals for the industries involved.

Two major alternatives to in vivo animal testing are in vitro cell culture techniques and. Alternatives to animal testing were proposed to overcome some of the drawbacks associated with animal experiments and avoid the unethical procedures. A strategy of 3 Rs is being applied which stands for reduction, refinement and replacement of laboratory use of animals ( Cited by:   That initiative led to publication of a volume on humane experimental approach that is now regarded as the foundation for the concept of the Three Rs of replacement, reduction, and refinement of animal studies.

[19] Ten years later, inMedawar correctly predicted that laboratory animal use would peak within ten years and then start to. Recording of a lecture on 22 November by Professor Michael Balls entitled On the Replacement of Animal Testing: Yesterday, Today, and Tomorrow which gives a detailed history of the development of the 3R tenet.

Norecopa and the 3Rs. By "alternatives" Norecopa means all the "three Rs" (Replacement, Reduction and Refinement) of Russell and Burch. Introduction: Progress in the Animal Research War By admin | Published: Janu Some years ago, Deborah Blum, a Pulitzer Prize–winning science journalist, nailed the divide between scientists who conduct research on animals in the hope of advancing medical knowledge and people who object to that work for being immoral and inhumane.Use of lab animals is minimized by applying the three Rs (replacement, reduction, refinement) The “three Rs” are a central concept in the use of animals in scientific research.

They stand for Replacement, Reduction and Refinement of animal experiments.The 3Rs: Replacement, Reduction, and Refinement, are important from a legal, ethical and scientific standpoint. All research using animals in the US, for example at universities and pharmaceutical companies, is regulated by the Animal Welfare Act (AWA), which is administered by the Animal and Plant Health Inspection Service (APHIS) of the US Department of Agriculture.